Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14987929 | 0.92 | MAPK1 (0.72) | MAPK1TDP1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL14987970 | 0.88 | MAPK1 (0.74) | MAPK1TDP1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL14987882 | 0.87 | MAPK1 (0.82) | MAPK1TDP1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL21257294 | 0.80 | ABCG2 (0.54) | MAPK1SMN1; SMN2ALDH1A1ABCG2CYP1A2 | |
| SCHEMBL16939622 | 0.80 | AHR (0.51) | SMN1; SMN2LMNAKDM4EMAPTALDH1A1 | |
| SCHEMBL21849530 | 0.78 | ABCG2 (0.53) | MAPK1SMN1; SMN2ALDH1A1ABCG2MAOA | |
| SCHEMBL14987893 | 0.78 | MAPK1 (1.00) | MAPK1TDP1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL31463144 | 0.77 | MYC (0.64) | MAPK1SMN1; SMN2LMNAKDM4EMAPT | |
| SCHEMBL21658469 | 0.77 | KDM4E (0.55) | SMN1; SMN2LMNAKDM4EALDH1A1ABCG2 | |
| SCHEMBL21882622 | 0.77 | KDM4E (0.55) | SMN1; SMN2LMNAKDM4EALDH1A1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8455489-B2 | Substituted pyrimidine compositions and methods of use | EXELIXIS, INC. (US) | 2013-06-04 | — | — | US | claimed |