Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 8/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.59 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.42 |
| ▸ | FLT1 | P17948 | 2/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14989004 | 0.95 | AURKA (0.58) | AURKAAURKBFGFR1FLT1PDGFRB | |
| SCHEMBL14989222 | 0.94 | AURKA (0.57) | AURKAAURKBFGFR1FLT1PDGFRB | |
| SCHEMBL14989122 | 0.94 | AURKA (0.57) | AURKAAURKBFGFR1FLT1PDGFRB | |
| SCHEMBL14989166 | 0.94 | AURKA (0.60) | AURKAAURKBFGFR1FLT1PDGFRB | |
| Hydrochloric Acid SCHEMBL14989099 | 0.93 | AURKB (0.56) | AURKAAURKBFGFR1FLT1NTRK1 | |
| SCHEMBL14989100 | 0.92 | AURKA (0.55) | AURKAAURKBFGFR1FLT1PDGFRB | |
| SCHEMBL14989091 | 0.92 | AURKA (0.56) | AURKAAURKBFGFR1FLT1PDGFRB | |
| SCHEMBL14989168 | 0.92 | AURKB (0.56) | AURKAAURKBFGFR1FLT1PDGFRB | |
| SCHEMBL14988946 | 0.92 | AURKA (0.59) | AURKAAURKBFGFR1FLT1PDGFRB | |
| SCHEMBL14989120 | 0.92 | AURKA (0.70) | AURKAAURKBFGFR1FLT1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1847532-B1 | IGF-1R INHIBITOR | KYOWA HAKKO KIRIN CO LTD (JP) | 2013-06-05 | — | — | EP | claimed |