Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 9/20 | 0.70 |
| ▸ | AURKA | O14965 | 8/20 | 0.70 |
| ▸ | CDK1 | P06493 | 3/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.41 |
| ▸ | CDK2 | P24941 | 3/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GALR3 | O60755 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14989354 | 1.00 | AURKB (0.70) | AURKBAURKACDK1CCNB1CDK2 | |
| SCHEMBL14989033 | 0.98 | AURKB (0.72) | AURKBAURKACDK1CCNB1CDK2 | |
| SCHEMBL14989031 | 0.98 | AURKB (0.72) | AURKBAURKACDK1CCNB1CDK2 | |
| Hydrochloric Acid SCHEMBL4314042 | 0.98 | AURKB (0.71) | AURKBAURKACDK1CCNB1CDK2 | |
| Hydrochloric Acid SCHEMBL4314035 | 0.98 | AURKB (0.71) | AURKBAURKACDK1CCNB1CDK2 | |
| SCHEMBL4313197 | 0.93 | AURKA (0.74) | AURKBAURKACDK5CDK5R1FGFR1 | |
| SCHEMBL4313205 | 0.93 | AURKA (0.74) | AURKBAURKACDK5CDK5R1FGFR1 | |
| SCHEMBL4326126 | 0.93 | AURKA (0.74) | AURKBAURKACDK5CDK5R1FGFR1 | |
| SCHEMBL4326122 | 0.93 | AURKA (0.74) | AURKBAURKACDK5CDK5R1FGFR1 | |
| SCHEMBL4317531 | 0.92 | AURKB (0.66) | AURKBAURKACDK1CCNB1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1847532-B1 | IGF-1R INHIBITOR | KYOWA HAKKO KIRIN CO LTD (JP) | 2013-06-05 | — | — | EP | claimed |