Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 18/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.44 |
| ▸ | STRADA | Q7RTN6 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14997615 | 0.95 | MAPKAPK2 (0.47) | MAPKAPK2MAPK14ROCK2MAPK12MAPK11 | |
| SCHEMBL14990075 | 0.94 | MAPKAPK2 (0.48) | MAPKAPK2MAPK14ROCK2MAPK12MAPK11 | |
| SCHEMBL14997646 | 0.93 | MAPKAPK2 (0.48) | MAPKAPK2MAPK14ROCK2MAPK12MAPK11 | |
| SCHEMBL14997647 | 0.92 | MAPKAPK2 (0.49) | MAPKAPK2MAPK14ROCK2MAPK12MAPK11 | |
| SCHEMBL14990168 | 0.92 | MAPKAPK2 (0.39) | MAPKAPK2MAPK14ROCK2MAPK12MAPK11 | |
| SCHEMBL14997644 | 0.92 | MAPKAPK2 (0.54) | MAPKAPK2MAPK14ROCK2MAPK12MAPK11 | |
| SCHEMBL14990017 | 0.90 | MAPKAPK2 (0.38) | MAPKAPK2MAPK14ROCK2MAPK12MAPK11 | |
| SCHEMBL14989671 | 0.90 | MAPKAPK5 (0.52) | MAPKAPK2MAPK14MAPK1MAPKAPK5 | |
| SCHEMBL14989843 | 0.90 | MAPK14 (0.40) | MAPKAPK2MAPK14ROCK2MAPK12MAPK11 | |
| SCHEMBL14990061 | 0.89 | MAPK14 (0.46) | MAPKAPK2MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9056110-B2 | Substituted pyrimidinone-phenyl-pyrimidinyl compounds | CONFLUENCE LIFE SCIENCES, INC. (US) | 2015-06-16 | — | — | US | disclosed |
| US-9056110-B2 | Substituted pyrimidinone-phenyl-pyrimidinyl compounds | CONFLUENCE LIFE SCIENCES, INC. (US) | 2015-06-16 | — | — | US | disclosed |
| WO-2013086208-A1 | SUBSTITUTED PYRIMIDINONE-PHENYL-PYRIMIDINYL COMPOUNDS | CONFLUENCE LIFE SCIENCES, INC. (US) | 2013-06-13 | — | — | WO | disclosed |
| US-20130143906-A1 | SUBSTITUTED PYRIMIDINONE-PHENYL-PYRIMIDINYL COMPOUNDS | CONFLUENCE LIFE SCIENCES, INC. (US) | 2013-06-06 | — | — | US | disclosed |
| US-20130143906-A1 | SUBSTITUTED PYRIMIDINONE-PHENYL-PYRIMIDINYL COMPOUNDS | CONFLUENCE LIFE SCIENCES, INC. (US) | 2013-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130143906-A1 | SUBSTITUTED PYRIMIDINONE-PHENYL-PYRIMIDINYL COMPOUNDS | MAP3K8, MAP3K1, MAP3K2 | MAPKAPK2 29/4885MAPK14 56/4885ROCK2 739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.