Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.50 |
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.43 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KAT6A | Q92794 | 3/20 | 0.39 |
| ▸ | F10 | P00742 | 2/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP7 | P09237 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3092105 | 0.88 | LARS1 (0.47) | LARS1CTSSNLRP3RAPGEF3L3MBTL1 | |
| SCHEMBL14999941 | 0.86 | LARS1 (0.53) | LARS1CTSSNLRP3RAPGEF3L3MBTL1 | |
| SCHEMBL3086119 | 0.86 | LARS1 (0.54) | LARS1CTSSNLRP3RAPGEF3L3MBTL1 | |
| SCHEMBL13151623 | 0.86 | LARS1 (0.57) | LARS1CTSSNLRP3RAPGEF3L3MBTL1 | |
| SCHEMBL3096612 | 0.84 | LARS1 (0.51) | LARS1CTSSNLRP3RAPGEF3L3MBTL1 | |
| SCHEMBL15000274 | 0.83 | LARS1 (0.52) | LARS1CTSSNLRP3RAPGEF3L3MBTL1 | |
| SCHEMBL14999890 | 0.82 | LARS1 (0.47) | LARS1CTSSNLRP3KAT6AF2 | |
| SCHEMBL3085973 | 0.82 | LARS1 (0.53) | LARS1NLRP3RAPGEF3L3MBTL1ALDH1A1 | |
| SCHEMBL15000276 | 0.82 | LARS1 (0.53) | LARS1NLRP3RAPGEF3L3MBTL1ALDH1A1 | |
| SCHEMBL15000268 | 0.81 | LARS1 (0.50) | LARS1ALDH1A1KDM4EKAT6AF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461209-B2 | Malonic acid sulfonamide derivative and pharmaceutical use thereof | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2013-06-11 | — | — | US | disclosed |