Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 11/20 | 0.76 |
| ▸ | JAK3 | P52333 | 8/20 | 0.76 |
| ▸ | TYK2 | P29597 | 5/20 | 0.76 |
| ▸ | JAK1 | P23458 | 15/20 | 0.75 |
| ▸ | AURKA | O14965 | 1/20 | 0.63 |
| ▸ | PRKCA | P17252 | 1/20 | 0.63 |
| ▸ | KDR | P35968 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2292143 | 0.91 | JAK2 (0.75) | JAK2JAK3TYK2JAK1 | |
| SCHEMBL2291263 | 0.88 | JAK1 (0.69) | JAK2JAK3TYK2JAK1 | |
| SCHEMBL14605165 | 0.88 | JAK1 (0.69) | JAK2JAK3TYK2JAK1 | |
| SCHEMBL21490735 | 0.86 | JAK3 (1.00) | JAK2JAK3TYK2JAK1 | |
| SCHEMBL21490737 | 0.86 | JAK3 (1.00) | JAK2JAK3TYK2JAK1 | |
| SCHEMBL14999954 | 0.86 | JAK1 (0.80) | JAK2JAK3TYK2JAK1AURKA | |
| SCHEMBL2226290 | 0.86 | JAK1 (1.00) | JAK2JAK3TYK2JAK1AURKA | |
| SCHEMBL2294629 | 0.86 | JAK2 (0.68) | JAK2JAK3TYK2JAK1 | |
| SCHEMBL2295474 | 0.84 | JAK2 (0.70) | JAK2JAK3TYK2JAK1 | |
| SCHEMBL14605266 | 0.84 | TYK2 (0.68) | JAK2JAK3TYK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461328-B2 | Tricyclic heterocyclic compounds, compositions and methods of use thereof | GENENTECH, INC. (US) | 2013-06-11 | — | — | US | disclosed |