Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 18/20 | 0.78 |
| ▸ | JAK2 | O60674 | 18/20 | 0.78 |
| ▸ | AURKA | O14965 | 1/20 | 0.72 |
| ▸ | PRKCA | P17252 | 1/20 | 0.72 |
| ▸ | KDR | P35968 | 1/20 | 0.72 |
| ▸ | TYK2 | P29597 | 3/20 | 0.66 |
| ▸ | JAK3 | P52333 | 3/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2292385 | 0.90 | JAK1 (0.79) | JAK1JAK2AURKAPRKCAKDR | |
| SCHEMBL12385424 | 0.90 | JAK1 (0.79) | JAK1JAK2AURKAPRKCAKDR | |
| SCHEMBL12385427 | 0.90 | JAK2 (0.90) | JAK1JAK2AURKAPRKCAKDR | |
| SCHEMBL2226061 | 0.89 | JAK2 (0.83) | JAK1JAK2AURKAPRKCAKDR | |
| SCHEMBL2298470 | 0.88 | JAK1 (1.00) | JAK1JAK2AURKAPRKCAKDR | |
| SCHEMBL12385554 | 0.88 | JAK1 (1.00) | JAK1JAK2AURKAPRKCAKDR | |
| SCHEMBL12385519 | 0.88 | JAK1 (1.00) | JAK1JAK2AURKAPRKCAKDR | |
| SCHEMBL2223442 | 0.86 | JAK1 (0.80) | JAK1JAK2AURKAPRKCAKDR | |
| SCHEMBL12385279 | 0.86 | JAK1 (0.80) | JAK1JAK2AURKAPRKCAKDR | |
| SCHEMBL12425866 | 0.85 | JAK1 (1.00) | JAK1JAK2AURKAPRKCAKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461328-B2 | Tricyclic heterocyclic compounds, compositions and methods of use thereof | GENENTECH, INC. (US) | 2013-06-11 | — | — | US | disclosed |