Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15001856 | 0.89 | SMN1; SMN2 (0.44) | SMN1; SMN2POLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL15001925 | 0.87 | GRM5 (0.50) | SMN1; SMN2POLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL15001846 | 0.87 | ESR1 (0.48) | SMN1; SMN2POLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL15001859 | 0.87 | MEN1 (0.44) | SMN1; SMN2POLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL15001872 | 0.87 | MEN1 (0.47) | SMN1; SMN2POLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL15001835 | 0.87 | TAAR1 (0.47) | SMN1; SMN2POLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL15001838 | 0.87 | SMN1; SMN2 (0.42) | SMN1; SMN2POLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL15001865 | 0.86 | MAPT (0.45) | SMN1; SMN2POLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL15001837 | 0.86 | SMN1; SMN2 (0.41) | SMN1; SMN2POLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL15001940 | 0.86 | KMT2A (0.62) | POLBKMT2AMEN1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8741892-B2 | Compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-06-03 | — | — | US | disclosed |
| US-20130143870-A1 | NOVEL COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-06-06 | — | — | US | disclosed |
| US-20130143870-A1 | NOVEL COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130143870-A1 | NOVEL COMPOUNDS | GRM5, GRM1, GRIK5 | SMN1; SMN2 2379/4885POLB 3617/4885KMT2A 1800/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.