Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 7/20 | 0.70 |
| ▸ | ABL1 | P00519 | 12/20 | 0.69 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | FLT3 | P36888 | 1/20 | 0.61 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29675112 | 0.92 | KIT (0.82) | KITABL1FGFR1FLT3 | |
| SCHEMBL24626017 | 0.92 | KIT (0.82) | KITABL1FGFR1FLT3 | |
| SCHEMBL13765822 | 0.91 | KIT (0.71) | KITABL1FGFR1FLT3 | |
| SCHEMBL4100122 | 0.89 | ABL1 (0.71) | KITABL1FGFR1CYP2C9PDGFRA | |
| SCHEMBL16683478 | 0.85 | ABL1 (0.68) | KITABL1FGFR1CYP2C9PDGFRA | |
| SCHEMBL19891571 | 0.85 | KIT (0.72) | KITABL1FGFR1PDGFRAFLT3 | |
| SCHEMBL13765888 | 0.84 | ABL1 (0.72) | KITABL1FGFR1CYP2C9PDGFRA | |
| SCHEMBL13765894 | 0.83 | ABL1 (0.85) | KITABL1FGFR1CYP2C9PDGFRA | |
| SCHEMBL16250590 | 0.83 | KIT (0.82) | KITABL1FGFR1CYP2C9PDGFRA | |
| SCHEMBL4097590 | 0.82 | ABL1 (0.74) | KITABL1FGFR1CYP2C9PDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461167-B2 | Acetylenic heteroaryl compounds | ARIAD PHARMACEUTICALS, INC. (US) | 2013-06-11 | — | — | US | disclosed |