⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19665529 | 0.67 | — | — | |
| SCHEMBL12630 | 0.66 | — | — | |
| SCHEMBL147332 | 0.64 | — | — | |
| SCHEMBL2184846 | 0.62 | — | — | |
| SCHEMBL28629064 | 0.62 | — | — | |
| SCHEMBL631210 | 0.62 | — | — | |
| SCHEMBL1564430 | 0.62 | — | — | |
| SCHEMBL13021 | 0.62 | — | — | |
| SCHEMBL1524605 | 0.60 | — | — | |
| SCHEMBL5345214 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2721026-B1 | PHOSPHATE ESTERS OF GYRASE AND TOPOISOMERASE INHIBITORS | VERTEX PHARMA (US) | 2016-03-02 | — | — | EP | claimed |
| US-9125922-B2 | Phosphate esters of gyrase and topoisomerase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-09-08 | — | — | US | claimed |
| US-20130157979-A1 | PHOSPHATE ESTERS OF GYRASE AND TOPOISOMERASE INHIBITORS | SPERO THERAPEUTICS, INC. | 2013-06-20 | — | — | US | claimed |
| EP-2721026-B1 | PHOSPHATE ESTERS OF GYRASE AND TOPOISOMERASE INHIBITORS | VERTEX PHARMA (US) | 2016-03-02 | — | — | EP | disclosed |
| US-9125922-B2 | Phosphate esters of gyrase and topoisomerase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-09-08 | — | — | US | disclosed |
| US-20130157979-A1 | PHOSPHATE ESTERS OF GYRASE AND TOPOISOMERASE INHIBITORS | SPERO THERAPEUTICS, INC. | 2013-06-20 | — | — | US | disclosed |