Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.66 |
| ▸ | EGFR | P00533 | 2/20 | 0.66 |
| ▸ | FRK | P42685 | 2/20 | 0.66 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.66 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.66 |
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.49 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.48 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.48 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 9/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15022105 | 0.84 | MAP4K4 (0.70) | MAP4K4EGFRFRKMAPK9CSNK1A1 | |
| SCHEMBL15022077 | 0.84 | PDE10A (0.63) | PDE10ACSNK1DCSNK1EMAPK13MAPK12 | |
| SCHEMBL15022347 | 0.80 | MAP4K4 (0.76) | MAP4K4EGFRFRKMAPK9CSNK1A1 | |
| SCHEMBL15043366 | 0.78 | MAP4K4 (0.55) | MAP4K4EGFRFRKMAPK9CSNK1A1 | |
| SCHEMBL15022065 | 0.76 | PDE10A (0.49) | MAP4K4EGFRFRKMAPK9CSNK1A1 | |
| SCHEMBL15022097 | 0.74 | PDE10A (0.67) | PDE10ACSNK1DCSNK1EMAPK13MAPK12 | |
| SCHEMBL15745979 | 0.70 | PDE10A (0.66) | PDE10ACSNK1DCSNK1EMAPK13MAPK12 | |
| SCHEMBL15022345 | 0.70 | MAPK13 (0.53) | PDE10ACSNK1DCSNK1EMAPK13MAPK12 | |
| SCHEMBL14414502 | 0.70 | MAP4K4 (0.60) | MAP4K4EGFRFRKMAPK9CSNK1A1 | |
| SCHEMBL15733493 | 0.69 | PDE10A (0.68) | PDE10ACSNK1DCSNK1EMAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130158031-A1 | ALKYNE-BRIDGED HETERO-AROMATICS AND USES THEREOF | SU ZHOU JING HONG BIOTECH CO., LTD. (CN) | 2013-06-20 | — | — | US | disclosed |
| US-20130158031-A1 | ALKYNE-BRIDGED HETERO-AROMATICS AND USES THEREOF | SU ZHOU JING HONG BIOTECH CO., LTD. (CN) | 2013-06-20 | — | — | US | disclosed |
| US-20130158031-A1 | ALKYNE-BRIDGED HETERO-AROMATICS AND USES THEREOF | SU ZHOU JING HONG BIOTECH CO., LTD. (CN) | 2013-06-20 | — | — | US | disclosed |
| CN-103159738-A | Mixed aromatic compound of alkynyl bridging and application thereof | SHANGHAI HONGBO ZHIYUAN MEDICAL TECHNOLOGY CO LTD | 2013-06-19 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130158031-A1 | ALKYNE-BRIDGED HETERO-AROMATICS AND USES THEREOF | CHRNA10, ATXN10, SCN10A | MAP4K4 2850/4885EGFR 3632/4885FRK 1630/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.