Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C2B | O00750 | 13/20 | 0.81 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.77 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.77 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.77 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.56 |
| ▸ | MTOR | P42345 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15023804 | 0.92 | PIK3C2B (0.79) | PIK3C2BPIK3CBPIK3CDPIK3R1PIK3CG | |
| SCHEMBL15023344 | 0.91 | PIK3C2B (0.73) | PIK3C2BPIK3CBPIK3CDPIK3R1PIK3CG | |
| SCHEMBL15023771 | 0.91 | PIK3C2B (0.68) | PIK3C2BPIK3CBPIK3CDPIK3R1PIK3CG | |
| SCHEMBL1281638 | 0.90 | PIK3C2B (0.82) | PIK3C2BPIK3CBPIK3CDPIK3R1PIK3CG | |
| SCHEMBL15022723 | 0.90 | PIK3C2B (0.67) | PIK3C2BPIK3CBPIK3CDPIK3R1PIK3CG | |
| SCHEMBL15023469 | 0.90 | PIK3C2B (0.71) | PIK3C2BPIK3CBPIK3CDPIK3R1PIK3CG | |
| SCHEMBL1281747 | 0.90 | PIK3C2B (1.00) | PIK3C2BPIK3CBPIK3CDPIK3R1PIK3CG | |
| SCHEMBL1281461 | 0.89 | PIK3C2B (1.00) | PIK3C2BPIK3CBPIK3CDPIK3R1PIK3CG | |
| SCHEMBL21085717 | 0.88 | PIK3C2B (0.77) | PIK3C2BPIK3CBPIK3CDPIK3R1PIK3CG | |
| SCHEMBL1633027 | 0.87 | PIK3C2B (0.87) | PIK3C2BPIK3CBPIK3CDPIK3R1PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8778937-B2 | Benzimidazole boronic acid derivatives as PI3 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2014-07-15 | — | — | US | claimed |
| US-20130157977-A1 | Benzimidazole Boronic Acid Derivatives As PI3 Kinase Inhibitors | GLAXOSMITHKLINE LLC (US) | 2013-06-20 | — | — | US | claimed |
| US-8778937-B2 | Benzimidazole boronic acid derivatives as PI3 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2014-07-15 | — | — | US | disclosed |
| US-8778937-B2 | Benzimidazole boronic acid derivatives as PI3 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2014-07-15 | — | — | US | disclosed |
| US-8778937-B2 | Benzimidazole boronic acid derivatives as PI3 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2014-07-15 | — | — | US | disclosed |
| US-20130157977-A1 | Benzimidazole Boronic Acid Derivatives As PI3 Kinase Inhibitors | GLAXOSMITHKLINE LLC (US) | 2013-06-20 | — | — | US | disclosed |
| US-20130157977-A1 | Benzimidazole Boronic Acid Derivatives As PI3 Kinase Inhibitors | GLAXOSMITHKLINE LLC (US) | 2013-06-20 | — | — | US | disclosed |
| US-20130157977-A1 | Benzimidazole Boronic Acid Derivatives As PI3 Kinase Inhibitors | GLAXOSMITHKLINE LLC (US) | 2013-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130157977-A1 | Benzimidazole Boronic Acid Derivatives As PI3 Kinase Inhibitors | PI4KB, PI4KA, PIK3CB | PIK3C2B 7/4885PIK3CB 3/4885PIK3CD 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.