Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 14/20 | 0.64 |
| ▸ | CCNA2 | P20248 | 12/20 | 0.64 |
| ▸ | CDK2 | P24941 | 12/20 | 0.64 |
| ▸ | CCNA1 | P78396 | 12/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17850056 | 0.89 | CHEK1 (0.56) | CHEK1CCNA2CDK2CCNA1MEN1 | |
| SCHEMBL21483 | 0.89 | CHEK1 (0.56) | CHEK1CCNA2CDK2CCNA1MEN1 | |
| SCHEMBL15007512 | 0.89 | CHEK1 (0.56) | CHEK1CCNA2CDK2CCNA1MEN1 | |
| SCHEMBL15007509 | 0.88 | CHEK1 (0.55) | CHEK1CCNA2CDK2CCNA1MEN1 | |
| SCHEMBL2148290 | 0.85 | CHEK1 (0.57) | CHEK1CCNA2CDK2CCNA1MEN1 | |
| SCHEMBL14246610 | 0.85 | CHEK1 (0.57) | CHEK1CCNA2CDK2CCNA1MEN1 | |
| SCHEMBL12460566 | 0.85 | CHEK1 (0.57) | CHEK1CCNA2CDK2CCNA1MEN1 | |
| SCHEMBL14245841 | 0.85 | CHEK1 (0.57) | CHEK1CCNA2CDK2CCNA1MEN1 | |
| SCHEMBL20761 | 0.85 | CHEK1 (0.52) | CHEK1CCNA2CDK2CCNA1MEN1 | |
| SCHEMBL20332 | 0.84 | CHEK1 (0.52) | CHEK1CCNA2CDK2CCNA1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8703784-B2 | Substituted pyrazolo[1,5-a]pyrido[3.2-e]pyrimidin-6-one inhibitors of mammalian target of rapamycin | MERCK SHARP & DOHME CORP. (US) | 2014-04-22 | — | — | US | disclosed |
| US-20130150353-A1 | Fused Tricyclic Inhibitors of Mammalian Target of Rapamycin | MERCK SHARP & DOHME LLC | 2013-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130150353-A1 | Fused Tricyclic Inhibitors of Mammalian Target of Rapamycin | MTOR, RICTOR, RPTOR | CHEK1 1496/4885CCNA2 1900/4885CDK2 379/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.