Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.46 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.46 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.46 |
| ▸ | NFE2 | Q16621 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15008960 | 0.86 | JAK2 (0.48) | JAK2NTRK1NTRK2MAPK14MAPK9 | |
| SCHEMBL399424 | 0.83 | MAPK14 (0.55) | JAK2NTRK1NTRK2MAPK14MAPK9 | |
| SCHEMBL3185484 | 0.80 | MAPK14 (0.73) | MAPK14MAPK9DDR2MAPK13MAPK12 | |
| SCHEMBL2083858 | 0.79 | MAPK14 (0.74) | MAPK14MAPK9DDR2MAPK13MAPK12 | |
| SCHEMBL13532240 | 0.79 | JAK2 (0.50) | JAK2NTRK1NTRK2MAPK14MAPK9 | |
| SCHEMBL2082640 | 0.78 | MAPK14 (0.72) | MAPK14MAPK11 | |
| SCHEMBL2083912 | 0.78 | MAPK14 (0.61) | MAPK14MAPK9DDR2MAPK13MAPK12 | |
| SCHEMBL2082244 | 0.77 | MAPK14 (0.68) | JAK2NTRK1NTRK2MAPK14MAPK9 | |
| SCHEMBL2083160 | 0.76 | MAPK14 (0.59) | JAK2NTRK1NTRK2MAPK14MAPK9 | |
| SCHEMBL4223376 | 0.76 | MAPK14 (0.73) | JAK2NTRK1NTRK2MAPK14MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013083604-A1 | KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-06-13 | — | — | WO | disclosed |