Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 12/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.44 |
| ▸ | PIK3R1 | P27986 | 7/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.44 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9950752 | 0.84 | PIK3CB (0.76) | PIK3CBKMT2AKDM4EMAPTRXFP1 | |
| SCHEMBL15029573 | 0.84 | PIK3CB (0.53) | PIK3CBALDH1A1KDM4EGAAHPGD | |
| SCHEMBL15029569 | 0.83 | PIK3CB (0.60) | PIK3CBKMT2APIK3CDPIK3CAPIK3R1 | |
| SCHEMBL15029840 | 0.80 | PIK3CB (0.57) | PIK3CBKMT2AKDM4EMAPTRXFP1 | |
| SCHEMBL15029844 | 0.80 | PIK3CB (0.57) | PIK3CBKMT2AKDM4EMAPTRXFP1 | |
| SCHEMBL10124146 | 0.78 | PIK3CB (0.57) | PIK3CBKMT2AKDM4EMAPTRXFP1 | |
| SCHEMBL10124151 | 0.78 | PIK3CB (0.57) | PIK3CBKMT2AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL15029576 | 0.77 | PIK3CB (0.56) | PIK3CBKMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL15029959 | 0.77 | PIK3CB (0.46) | PIK3CBPIK3CDPIK3CAPIK3R1PIK3CG | |
| SCHEMBL15029918 | 0.76 | PIK3CB (0.45) | PIK3CBALDH1A1KDM4EGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8912180-B2 | Heterocyclic compound | ASTELLAS PHARMA INC. (JP) | 2014-12-16 | — | — | US | disclosed |
| US-8912180-B2 | Heterocyclic compound | ASTELLAS PHARMA INC. (JP) | 2014-12-16 | — | — | US | disclosed |
| US-20130150364-A1 | HETEROCYCLIC COMPOUND | ASTELLAS PHARMA INC. (JP) | 2013-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130150364-A1 | HETEROCYCLIC COMPOUND | IL2, NFATC1, ICOS | PIK3CB 16/4885KMT2A 1663/4885ALDH1A1 1855/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.