Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 17/20 | 0.59 |
| ▸ | PIK3CA | P42336 | 14/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 13/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 12/20 | 0.53 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.53 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.53 |
| ▸ | MTOR | P42345 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | APAF1 | O14727 | 1/20 | 0.47 |
| ▸ | NSD2 | O96028 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | GALK1 | P51570 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15029786 | 0.89 | PIK3CB (0.67) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL15029400 | 0.87 | PIK3CB (0.64) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL15029648 | 0.87 | PIK3CB (0.64) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL16308216 | 0.86 | PIK3CB (0.63) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL15029892 | 0.82 | PIK3CB (0.62) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL16308219 | 0.80 | PIK3CB (0.58) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL15029396 | 0.80 | PIK3CB (0.54) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL15029393 | 0.80 | PIK3CB (0.54) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL16308218 | 0.80 | PIK3CB (0.54) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL16308217 | 0.79 | PIK3CB (0.54) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2604601-B1 | HETERO RING COMPOUND | ASTELLAS PHARMA INC (JP) | 2016-02-24 | — | — | EP | disclosed |
| US-8912180-B2 | Heterocyclic compound | ASTELLAS PHARMA INC. (JP) | 2014-12-16 | — | — | US | disclosed |
| US-8912180-B2 | Heterocyclic compound | ASTELLAS PHARMA INC. (JP) | 2014-12-16 | — | — | US | disclosed |
| US-20130150364-A1 | HETEROCYCLIC COMPOUND | ASTELLAS PHARMA INC. (JP) | 2013-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130150364-A1 | HETEROCYCLIC COMPOUND | IL2, NFATC1, ICOS | PIK3CB 16/4885PIK3CA 28/4885PIK3CD 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.