Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 8/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16308083 | 0.86 | KMT2A (0.45) | PIK3CBPIK3CDPIK3CAKMT2AMAPT | |
| SCHEMBL9950895 | 0.85 | KMT2A (0.44) | PIK3CBPIK3CDPIK3CAKMT2AMAPT | |
| SCHEMBL15009018 | 0.85 | KMT2A (0.44) | PIK3CBPIK3CDPIK3CAKMT2AMAPT | |
| SCHEMBL15029886 | 0.83 | PIK3CB (0.68) | PIK3CBPIK3CDPIK3CAKMT2AALDH1A1 | |
| SCHEMBL9950056 | 0.83 | PIK3CB (0.49) | PIK3CBPIK3CDPIK3CAKMT2AMAPT | |
| SCHEMBL15029570 | 0.83 | KMT2A (0.42) | PIK3CBPIK3CDPIK3CAKMT2AS1PR1 | |
| SCHEMBL15029841 | 0.79 | KMT2A (0.44) | PIK3CBPIK3CDPIK3CAKMT2AMAPT | |
| SCHEMBL9950249 | 0.79 | KMT2A (0.44) | PIK3CBPIK3CDPIK3CAKMT2AMAPT | |
| SCHEMBL909630 | 0.77 | PIK3CB (0.56) | PIK3CBPIK3CDPIK3CAKMT2A | |
| SCHEMBL15009622 | 0.74 | PIK3CB (0.57) | PIK3CBPIK3CDPIK3CAMAPTPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8912180-B2 | Heterocyclic compound | ASTELLAS PHARMA INC. (JP) | 2014-12-16 | — | — | US | disclosed |
| US-8912180-B2 | Heterocyclic compound | ASTELLAS PHARMA INC. (JP) | 2014-12-16 | — | — | US | disclosed |
| US-20130150364-A1 | HETEROCYCLIC COMPOUND | ASTELLAS PHARMA INC. (JP) | 2013-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130150364-A1 | HETEROCYCLIC COMPOUND | IL2, NFATC1, ICOS | PIK3CB 16/4885PIK3CD 6/4885PIK3CA 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.