Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 17/20 | 0.67 |
| ▸ | PRKDC | P78527 | 1/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.36 |
| ▸ | TTK | P33981 | 2/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10142425 | 0.92 | PIK3CG (0.77) | PIK3CGPRKDCPIK3CDPIK3CATTK | |
| SCHEMBL10143000 | 0.90 | PIK3CG (0.67) | PIK3CGPRKDCPIK3CDPIK3CATTK | |
| SCHEMBL10142998 | 0.90 | PIK3CG (0.67) | PIK3CGPRKDCPIK3CDPIK3CATTK | |
| SCHEMBL10142750 | 0.90 | PIK3CG (0.67) | PIK3CGPRKDCPIK3CDPIK3CATTK | |
| SCHEMBL10142745 | 0.90 | PIK3CG (0.67) | PIK3CGPRKDCPIK3CDPIK3CATTK | |
| SCHEMBL10143021 | 0.88 | PIK3CG (0.65) | PIK3CGPRKDCPIK3CDPIK3CATTK | |
| SCHEMBL10142955 | 0.88 | PIK3CG (0.65) | PIK3CGPRKDCPIK3CDPIK3CATTK | |
| SCHEMBL10143016 | 0.88 | PIK3CG (0.65) | PIK3CGPRKDCPIK3CDPIK3CATTK | |
| SCHEMBL10142872 | 0.88 | PIK3CG (0.64) | PIK3CGPRKDCPIK3CDPIK3CATTK | |
| SCHEMBL10142953 | 0.87 | PIK3CG (0.63) | PIK3CGPRKDCPIK3CDPIK3CATTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8466288-B2 | Isoindolinone inhibitors of phosphatidylinositol 3-kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-06-18 | — | — | US | disclosed |
| US-8466288-B2 | Isoindolinone inhibitors of phosphatidylinositol 3-kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-06-18 | — | — | US | disclosed |