Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.69 |
| ▸ | JAK3 | P52333 | 20/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15032581 | 0.82 | JAK2 (0.85) | JAK2JAK3 | |
| SCHEMBL15032785 | 0.82 | JAK2 (1.00) | JAK2JAK3 | |
| SCHEMBL16245302 | 0.81 | JAK2 (0.84) | JAK2JAK3 | |
| SCHEMBL16244764 | 0.81 | JAK3 (0.70) | JAK2JAK3 | |
| SCHEMBL16245016 | 0.81 | JAK3 (1.00) | JAK2JAK3 | |
| SCHEMBL15032719 | 0.80 | JAK2 (1.00) | JAK2JAK3 | |
| SCHEMBL15032695 | 0.80 | JAK2 (0.78) | JAK2JAK3 | |
| SCHEMBL15032792 | 0.80 | JAK2 (0.85) | JAK2JAK3 | |
| SCHEMBL15032794 | 0.80 | JAK2 (1.00) | JAK2JAK3 | |
| SCHEMBL16245118 | 0.80 | JAK2 (1.00) | JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013085802-A1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-06-13 | — | — | WO | disclosed |