Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKN1 | Q16512 | 5/20 | 0.46 |
| ▸ | PAK4 | O96013 | 4/20 | 0.46 |
| ▸ | PAK1 | Q13153 | 6/20 | 0.45 |
| ▸ | PAK2 | Q13177 | 5/20 | 0.45 |
| ▸ | PAK3 | O75914 | 3/20 | 0.45 |
| ▸ | TNK2 | Q07912 | 5/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 4/20 | 0.40 |
| ▸ | STK4 | Q13043 | 1/20 | 0.40 |
| ▸ | STK3 | Q13188 | 1/20 | 0.40 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.40 |
| ▸ | STK26 | Q9P289 | 1/20 | 0.40 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.40 |
| ▸ | WEE1 | P30291 | 1/20 | 0.39 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15237029 | 0.86 | PKN1 (0.47) | PKN1PAK4PAK1PAK2PAK3 | |
| SCHEMBL15034906 | 0.80 | PKN1 (0.49) | PKN1PAK4PAK1PAK2PAK3 | |
| SCHEMBL15035745 | 0.77 | RIPK2 (0.48) | PKN1PAK4PAK1PAK2PAK3 | |
| SCHEMBL15035053 | 0.75 | PKN1 (0.43) | PKN1PAK4PAK1PAK2PAK3 | |
| SCHEMBL15035665 | 0.75 | PKN1 (0.45) | PKN1PAK4PAK1PAK2PAK3 | |
| SCHEMBL15034892 | 0.74 | FGFR1 (0.35) | PKN1PAK4PAK1PAK2PAK3 | |
| SCHEMBL15035427 | 0.73 | AXL (0.46) | PKN1PAK4PAK1PAK2PAK3 | |
| SCHEMBL15034987 | 0.73 | CDK4 (0.45) | SRC | |
| SCHEMBL15277155 | 0.73 | PKN1 (0.56) | PKN1PAK4PAK1PAK2PAK3 | |
| SCHEMBL15034912 | 0.72 | RIPK2 (0.36) | TNK2SRCSTK4STK3SIK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130231348-A1 | 8-(HETEROARYLMETHYL)PYRIDO[2,3-d]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS | AFRAXIS, INC. (US) | 2013-09-05 | — | — | US | disclosed |
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | AFRAXIS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130231348-A1 | 8-(HETEROARYLMETHYL)PYRIDO[2,3-d]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS | PAK2, PAK3, PAK5 | PKN1 604/4885PAK4 5/4885PAK1 6/4885 |
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | PAK5, PAK2, PAK6 | PKN1 326/4885PAK4 5/4885PAK1 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.