Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 5/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | USP2 | O75604 | 4/20 | 0.33 |
| ▸ | CASP1 | P29466 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | CASP7 | P55210 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.33 |
| ▸ | PAK3 | O75914 | 2/20 | 0.32 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.32 |
| ▸ | PAK2 | Q13177 | 2/20 | 0.32 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15041769 | 0.93 | CDK4 (0.38) | CDK4CDK6MEN1USP2CASP1 | |
| SCHEMBL15041732 | 0.80 | FGFR1 (0.39) | CDK4CDK6JAK3FGFR1CCNA2 | |
| SCHEMBL15036315 | 0.79 | FGFR1 (0.40) | CDK4CDK6FGFR1CCNA2FGFR2 | |
| SCHEMBL15036198 | 0.77 | CDK4 (0.39) | CDK4CDK6JAK3FGFR1CCNA2 | |
| SCHEMBL15041544 | 0.77 | CDK4 (0.39) | CDK4CDK6JAK3FGFR1CCND1 | |
| SCHEMBL15034855 | 0.76 | CDK4 (0.37) | CDK4CDK6PAK3PAK1PAK2 | |
| SCHEMBL15035073 | 0.76 | CDK4 (0.39) | CDK4CDK6JAK3FGFR1CCNA2 | |
| SCHEMBL15035931 | 0.75 | CDK4 (0.36) | CDK4CDK6JAK3CCNA2CCND1 | |
| SCHEMBL15036177 | 0.74 | PTK2 (0.36) | CDK4CDK6JAK3FGFR1CCNA2 | |
| SCHEMBL15035723 | 0.73 | CDK4 (0.39) | CDK4CDK6JAK3FGFR1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130231348-A1 | 8-(HETEROARYLMETHYL)PYRIDO[2,3-d]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS | AFRAXIS, INC. (US) | 2013-09-05 | — | — | US | disclosed |
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | AFRAXIS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130231348-A1 | 8-(HETEROARYLMETHYL)PYRIDO[2,3-d]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS | PAK2, PAK3, PAK5 | CDK4 408/4885CDK6 299/4885MEN1 2261/4885 |
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | PAK5, PAK2, PAK6 | CDK4 404/4885CDK6 435/4885MEN1 2982/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.