Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 3/20 | 0.48 |
| ▸ | PKN1 | Q16512 | 3/20 | 0.48 |
| ▸ | PAK3 | O75914 | 2/20 | 0.48 |
| ▸ | PAK2 | Q13177 | 2/20 | 0.48 |
| ▸ | CDK4 | P11802 | 15/20 | 0.43 |
| ▸ | CCND1 | P24385 | 14/20 | 0.43 |
| ▸ | CDK2 | P24941 | 14/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 12/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 9/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.43 |
| ▸ | CDK9 | P50750 | 3/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.43 |
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.43 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15787961 | 0.93 | PAK1 (0.52) | PAK1PKN1PAK3PAK2CDK4 | |
| SCHEMBL14682037 | 0.87 | PAK1 (0.47) | PAK1PKN1PAK3PAK2CDK4 | |
| SCHEMBL13553761 | 0.87 | CCND1 (0.44) | PAK1PKN1CDK4CCND1CDK2 | |
| SCHEMBL15036367 | 0.76 | CDK4 (0.60) | PAK1PKN1CDK4CCND1CDK2 | |
| SCHEMBL15041864 | 0.75 | CDK4 (0.46) | PAK1PKN1CDK4CCND1CDK2 | |
| SCHEMBL15787912 | 0.73 | CCND1 (0.47) | PAK1PKN1CDK4CCND1CDK2 | |
| SCHEMBL15787918 | 0.71 | PAK1 (0.50) | PAK1PKN1PAK3PAK2PAK4 | |
| SCHEMBL14682121 | 0.71 | CCNE1 (0.47) | CDK4CCND1CDK2CCNE1CDK9 | |
| SCHEMBL13553927 | 0.70 | CCND1 (0.40) | PAK1PKN1PAK3PAK2CDK4 | |
| SCHEMBL15787839 | 0.70 | CDK4 (0.52) | CDK4CCND1CDK2CCNA2FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | AFRAXIS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | AFRAXIS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | PAK5, PAK2, PAK6 | PAK1 4/4885PKN1 326/4885PAK3 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.