Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 2/20 | 0.42 |
| ▸ | PAK2 | Q13177 | 2/20 | 0.42 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.40 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15035252 | 0.89 | PAK1 (0.43) | PAK1PAK2TNK2RIPK2NOD2 | |
| SCHEMBL15035341 | 0.87 | RIPK2 (0.41) | PAK1PAK2TNK2RIPK2NOD2 | |
| SCHEMBL15035254 | 0.83 | PAK1 (0.42) | PAK1PAK2TNK2RIPK2NOD2 | |
| SCHEMBL15035270 | 0.83 | PAK1 (0.54) | PAK1PAK2TNK2RIPK2NOD2 | |
| SCHEMBL15035261 | 0.81 | PAK1 (0.43) | PAK1PAK2TNK2RIPK2NOD2 | |
| SCHEMBL15035259 | 0.80 | PAK4 (0.42) | PAK1PAK2TNK2RIPK2NOD2 | |
| SCHEMBL15035256 | 0.80 | PAK1 (0.42) | PAK1PAK2TNK2RIPK2NOD2 | |
| SCHEMBL15035246 | 0.79 | CDK4 (0.43) | TNK2RIPK2NOD2 | |
| SCHEMBL16510429 | 0.77 | PAK1 (0.62) | PAK1PAK2TNK2 | |
| SCHEMBL15035272 | 0.76 | FGFR1 (0.57) | PAK1PAK2TNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | AFRAXIS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | PAK5, PAK2, PAK6 | PAK1 4/4885PAK2 2/4885TNK2 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.