Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 5/20 | 0.51 |
| ▸ | AURKA | O14965 | 2/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.48 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 6/20 | 0.45 |
| ▸ | CCND3 | P30281 | 5/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.45 |
| ▸ | CDK2 | P24941 | 4/20 | 0.45 |
| ▸ | CCNK | O75909 | 2/20 | 0.45 |
| ▸ | CDK9 | P50750 | 2/20 | 0.45 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.45 |
| ▸ | CCND1 | P24385 | 3/20 | 0.44 |
| ▸ | CCND2 | P30279 | 3/20 | 0.44 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.44 |
| ▸ | SRC | P12931 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15035284 | 0.86 | CDK4 (0.51) | CDK4AURKAALKTNK2EGFR | |
| SCHEMBL15035278 | 0.85 | CDK4 (0.50) | CDK4AURKAALKTNK2EGFR | |
| SCHEMBL15035271 | 0.85 | CDK4 (0.50) | CDK4AURKAALKTNK2EGFR | |
| SCHEMBL15041300 | 0.77 | CDK4 (0.73) | CDK4AURKATNK2EGFRCCND3 | |
| SCHEMBL15035280 | 0.76 | TNK2 (0.52) | CDK4AURKAALKTNK2EGFR | |
| SCHEMBL10192607 | 0.75 | ALK (0.49) | CDK4ALKEGFRCDK2CCND1 | |
| SCHEMBL15035263 | 0.74 | TNK2 (0.48) | CDK4AURKAALKTNK2EGFR | |
| SCHEMBL22680883 | 0.71 | TNK2 (0.56) | CDK4AURKAALKTNK2EGFR | |
| SCHEMBL15035281 | 0.70 | FGFR1 (0.58) | CDK4AURKATNK2EGFRCCND3 | |
| SCHEMBL16510428 | 0.69 | PAK1 (0.65) | CDK4AURKATNK2EGFRCCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | AFRAXIS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | PAK5, PAK2, PAK6 | CDK4 404/4885AURKA 653/4885ALK 2737/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.