Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 15/20 | 0.38 |
| ▸ | CCND1 | P24385 | 15/20 | 0.38 |
| ▸ | CDK2 | P24941 | 15/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 13/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 11/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 10/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 10/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 10/20 | 0.38 |
| ▸ | CCND2 | P30279 | 1/20 | 0.36 |
| ▸ | CCND3 | P30281 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.35 |
| ▸ | CDK9 | P50750 | 3/20 | 0.35 |
| ▸ | CDK7 | P50613 | 2/20 | 0.35 |
| ▸ | CCNH | P51946 | 2/20 | 0.35 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15035436 | 0.83 | CDK4 (0.42) | CDK4CCND1CDK2CCNA2FGFR1 | |
| SCHEMBL15035383 | 0.79 | CDK4 (0.39) | CDK4CCND1CDK2CCNA2FGFR1 | |
| SCHEMBL15035586 | 0.78 | CDK4 (0.40) | CDK4CCND1CDK2CCNA2FGFR1 | |
| SCHEMBL15041322 | 0.77 | CDK4 (0.47) | CDK4CCND1CDK2CCNA2FGFR1 | |
| SCHEMBL15035542 | 0.77 | CDK2 (0.38) | CDK4CCND1CDK2CCNA2FGFR1 | |
| SCHEMBL15034983 | 0.74 | CDK2 (0.39) | CDK4CCND1CDK2CCNA2FGFR1 | |
| SCHEMBL15035400 | 0.74 | CDK4 (0.36) | CDK4CCND1CDK2CCNA2FGFR1 | |
| SCHEMBL15035480 | 0.74 | CDK4 (0.38) | CDK4CCND1CDK2CCNA2FGFR1 | |
| SCHEMBL15035482 | 0.73 | — | — | |
| SCHEMBL15035424 | 0.72 | TNK2 (0.48) | CDK4CCND1CDK2CCNA2FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | AFRAXIS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | AFRAXIS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | PAK5, PAK2, PAK6 | CDK4 404/4885CCND1 2153/4885CDK2 183/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.