Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 10/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.38 |
| ▸ | BRD4 | O60885 | 3/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | BRD2 | P25440 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.38 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 9/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.38 |
| ▸ | CDK2 | P24941 | 8/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 7/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 6/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 6/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | CCND2 | P30279 | 1/20 | 0.35 |
| ▸ | CCND3 | P30281 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15035350 | 0.83 | CDK4 (0.38) | CDK4CDK6JAK2BRD4JAK1 | |
| SCHEMBL15035558 | 0.81 | CDK4 (0.41) | CDK4CDK6JAK2BRD4JAK1 | |
| SCHEMBL15035515 | 0.77 | CDK4 (0.35) | CDK4CCND1CCNA2CDK2FGFR1 | |
| SCHEMBL15035296 | 0.76 | CDK4 (0.54) | CDK4CCND1CCNA2CDK2FGFR1 | |
| SCHEMBL15035537 | 0.76 | CDK4 (0.39) | CDK4JAK2JAK1JAK3CCND1 | |
| SCHEMBL15035480 | 0.75 | CDK4 (0.38) | CDK4CDK6CCND1CCNA2CDK2 | |
| SCHEMBL15035740 | 0.74 | RIPK2 (0.43) | CDK4JAK2BRD4JAK1BRD2 | |
| SCHEMBL15035472 | 0.74 | CDK4 (0.40) | CDK4JAK2BRD4JAK1BRD2 | |
| SCHEMBL15034932 | 0.74 | PAK4 (0.42) | CDK4CDK6JAK2BRD4JAK1 | |
| SCHEMBL15035037 | 0.73 | PAK4 (0.38) | CDK4JAK2BRD4JAK1BRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | AFRAXIS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | AFRAXIS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | PAK5, PAK2, PAK6 | CDK4 404/4885CDK6 435/4885JAK2 720/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.