Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 8/20 | 0.37 |
| ▸ | SRC | P12931 | 5/20 | 0.37 |
| ▸ | TNK2 | Q07912 | 4/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15035387 | 0.81 | CDK4 (0.37) | WEE1SRCTNK2FGFR1FGFR2 | |
| SCHEMBL15035769 | 0.77 | WEE1 (0.39) | WEE1SRCTNK2FGFR1EGFR | |
| SCHEMBL15035440 | 0.76 | TNK2 (0.42) | WEE1SRCTNK2FGFR1FGFR2 | |
| SCHEMBL15237008 | 0.74 | PKN1 (0.40) | WEE1SRCTNK2FGFR1PDGFRB | |
| SCHEMBL15041829 | 0.74 | CDK4 (0.46) | WEE1TNK2FGFR1FGFR2FGFR4 | |
| SCHEMBL15035853 | 0.74 | WEE1 (0.38) | WEE1SRCTNK2FGFR1FGFR2 | |
| SCHEMBL15035574 | 0.73 | CDK4 (0.49) | WEE1SRCTNK2FGFR1FGFR2 | |
| SCHEMBL15035472 | 0.72 | CDK4 (0.40) | FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL15034998 | 0.71 | PKN1 (0.38) | WEE1TNK2 | |
| SCHEMBL15035411 | 0.71 | WEE1 (0.45) | WEE1TNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | AFRAXIS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | AFRAXIS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | PAK5, PAK2, PAK6 | WEE1 545/4885SRC 26/4885TNK2 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.