Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
| ▸ | PAK3 | O75914 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.38 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.38 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.38 |
| ▸ | PAK2 | Q13177 | 1/20 | 0.38 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 6/20 | 0.38 |
| ▸ | JAK2 | O60674 | 3/20 | 0.38 |
| ▸ | MTOR | P42345 | 7/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | BRD2 | P25440 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.37 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.37 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15277170 | 0.95 | BRD4 (0.40) | CCNA2CDK2CCNA1PAK3PAK4 | |
| SCHEMBL15041635 | 0.81 | BRD4 (0.42) | CCNA2CDK2CCNA1PAK3PAK4 | |
| SCHEMBL15035040 | 0.81 | CCNA2 (0.41) | CCNA2CDK2CCNA1PAK3PAK4 | |
| SCHEMBL15034828 | 0.81 | CCNA2 (0.41) | CCNA2CDK2CCNA1PAK3PAK4 | |
| SCHEMBL15034936 | 0.79 | CCNA2 (0.39) | CCNA2CDK2CCNA1PAK3PAK4 | |
| SCHEMBL15035738 | 0.76 | CCNA2 (0.39) | CCNA2CDK2CCNA1PAK3PAK4 | |
| SCHEMBL15035557 | 0.73 | CDK2 (0.43) | CCNA2CDK2CCNA1PAK3PAK4 | |
| SCHEMBL15035455 | 0.72 | CCNA2 (0.43) | CCNA2CDK2CCNA1PAK3PAK4 | |
| SCHEMBL15035351 | 0.72 | CDK2 (0.45) | CCNA2CDK2CCNA1PAK3PAK4 | |
| SCHEMBL15041545 | 0.69 | PAK3 (0.52) | CCNA2CDK2PAK3PAK4LIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130252967-A1 | 8-(SULFONYLBENZYL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS | AFRAXIS, INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | AFRAXIS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | AFRAXIS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130252967-A1 | 8-(SULFONYLBENZYL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS | PAK2, PAK3, PAK6 | CCNA2 3343/4885CDK2 211/4885CCNA1 4127/4885 |
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | PAK5, PAK2, PAK6 | CCNA2 2011/4885CDK2 183/4885CCNA1 1938/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.