Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 2/20 | 0.44 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 10/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 6/20 | 0.40 |
| ▸ | NOD2 | Q9HC29 | 6/20 | 0.40 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | STK4 | Q13043 | 1/20 | 0.37 |
| ▸ | STK3 | Q13188 | 1/20 | 0.37 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.37 |
| ▸ | STK26 | Q9P289 | 1/20 | 0.37 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.37 |
| ▸ | WEE1 | P30291 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15041460 | 0.94 | CDK4 (0.40) | CDK4CDK6RIPK2ACVR1NOD2 | |
| SCHEMBL16309189 | 0.89 | JAK2 (0.44) | CDK4CDK6RIPK2ACVR1NOD2 | |
| SCHEMBL15036154 | 0.81 | CDK4 (0.44) | CDK4CDK6RIPK2ACVR1NOD2 | |
| SCHEMBL14682052 | 0.77 | PKN1 (0.43) | RIPK2ACVR1NOD2SRCSTK4 | |
| SCHEMBL15036122 | 0.73 | RIPK2 (0.47) | RIPK2ACVR1NOD2TNK2SRC | |
| SCHEMBL15036147 | 0.73 | PAK3 (0.52) | CDK4CDK6TNK2SRCWEE1 | |
| SCHEMBL15041446 | 0.73 | PAK4 (0.43) | TNK2WEE1 | |
| SCHEMBL15041707 | 0.72 | RIPK2 (0.43) | RIPK2ACVR1NOD2TNK2WEE1 | |
| SCHEMBL15036055 | 0.71 | RIPK2 (0.46) | RIPK2ACVR1NOD2TNK2SRC | |
| SCHEMBL15041420 | 0.71 | CDK4 (0.46) | CDK4CDK6RIPK2ACVR1NOD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | AFRAXIS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | PAK5, PAK2, PAK6 | CDK4 404/4885CDK6 435/4885RIPK2 971/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.