Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 3/20 | 0.38 |
| ▸ | CCNK | O75909 | 11/20 | 0.38 |
| ▸ | CDK12 | Q9NYV4 | 11/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 9/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 9/20 | 0.38 |
| ▸ | CDK2 | P24941 | 9/20 | 0.38 |
| ▸ | CDK9 | P50750 | 9/20 | 0.38 |
| ▸ | CDK7 | P50613 | 4/20 | 0.38 |
| ▸ | CCNH | P51946 | 4/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | WEE1 | P30291 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CCND2 | P30279 | 1/20 | 0.37 |
| ▸ | CCND3 | P30281 | 1/20 | 0.37 |
| ▸ | MNAT1 | P51948 | 3/20 | 0.37 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15041518 | 0.92 | CHEK1 (0.37) | CHEK1CCNKCDK12CCNT1CCNE1 | |
| SCHEMBL15036010 | 0.82 | TNK2 (0.44) | CHEK1CCNKCDK12CCNT1CCNE1 | |
| SCHEMBL15036051 | 0.78 | CDK7 (0.48) | CCNKCDK12CCNT1CCNE1CDK2 | |
| SCHEMBL15036135 | 0.75 | WEE1 (0.43) | CDK2WEE1CDK4CCND1CCND2 | |
| SCHEMBL15035997 | 0.74 | WEE1 (0.38) | CDK2WEE1CDK4CCND1CCND2 | |
| SCHEMBL14682063 | 0.73 | CDK4 (0.38) | CHEK1CCNT1CDK2CDK9CDK7 | |
| SCHEMBL15281037 | 0.73 | WEE1 (0.40) | CDK2WEE1CDK4CCND1CCND2 | |
| SCHEMBL10246428 | 0.72 | WEE1 (0.44) | CHEK1CCNKCDK12CCNT1CCNE1 | |
| SCHEMBL13553810 | 0.72 | CDK4 (0.37) | CDK2WEE1CDK4CCND1CCND2 | |
| SCHEMBL15041262 | 0.71 | CDK4 (0.39) | CCNT1CDK2CDK9CDK7CCNH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130252966-A1 | 6-(SULFONYLARYL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS | AFRAXIS, INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | AFRAXIS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130252966-A1 | 6-(SULFONYLARYL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS | PAK2, PAK6, PAK3 | CHEK1 947/4885CCNK 2036/4885CDK12 1211/4885 |
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | PAK5, PAK2, PAK6 | CHEK1 212/4885CCNK 757/4885CDK12 895/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.