Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 12/20 | 0.39 |
| ▸ | CCND1 | P24385 | 12/20 | 0.39 |
| ▸ | CCND2 | P30279 | 3/20 | 0.39 |
| ▸ | CCND3 | P30281 | 3/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.38 |
| ▸ | CDK2 | P24941 | 7/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 6/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 6/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 6/20 | 0.38 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.38 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.38 |
| ▸ | WEE1 | P30291 | 1/20 | 0.37 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15041734 | 0.97 | MAP4K3 (0.39) | CDK4CCND1CCND2CCND3CCNA2 | |
| SCHEMBL15258273 | 0.93 | MAP4K3 (0.37) | CDK4CCND1CCND2CCND3CCNA2 | |
| SCHEMBL15618064 | 0.91 | CCND1 (0.37) | CDK4CCND1CCND2CCND3CCNA2 | |
| SCHEMBL15036470 | 0.84 | CDK4 (0.39) | CDK4CCND1CCND2CCND3CCNA2 | |
| SCHEMBL15617470 | 0.83 | CCND1 (0.38) | CDK4CCND1CCND2CCND3CCNA2 | |
| SCHEMBL15036183 | 0.82 | CDK4 (0.38) | CDK4CCND1CCND2CCND3CCNA2 | |
| SCHEMBL15041563 | 0.81 | PTK2 (0.49) | JAK3PTK2FLT4 | |
| SCHEMBL15258232 | 0.81 | CDK4 (0.36) | CDK4CCND1CCND2CCND3CCNA2 | |
| SCHEMBL15617431 | 0.80 | AXL (0.37) | CDK4CCND1CCNA2CDK2FGFR1 | |
| SCHEMBL16511400 | 0.79 | PTK2 (0.51) | WEE1PTK2FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | AFRAXIS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | PAK5, PAK2, PAK6 | CDK4 404/4885CCND1 2153/4885CCND2 2332/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.