Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.72 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 5/20 | 0.46 |
| ▸ | ATF1 | P18846 | 2/20 | 0.46 |
| ▸ | CFTR | P13569 | 2/20 | 0.46 |
| ▸ | JUN | P05412 | 3/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.43 |
| ▸ | RELA | Q04206 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12775325 | 0.86 | KDM4E (0.54) | KDM4EMAPTGAAALDH1A1CFTR | |
| SCHEMBL3922065 | 0.84 | KDM4E (1.00) | KDM4EMAPTALDH1A1KMT2ANFKB1 | |
| SCHEMBL4592101 | 0.83 | MAPT (0.57) | KDM4EMAPTGAAALDH1A1KMT2A | |
| SCHEMBL6475927 | 0.82 | MAPT (0.60) | KDM4EMAPTGAAALDH1A1KMT2A | |
| Water SCHEMBL4593114 | 0.81 | MAPT (0.56) | KDM4EMAPTGAAALDH1A1KMT2A | |
| SCHEMBL473934 | 0.81 | ATF1 (0.62) | KDM4EMAPTGAAALDH1A1KMT2A | |
| SCHEMBL1759818 | 0.81 | MAPT (0.53) | KDM4EMAPTGAAALDH1A1KMT2A | |
| SCHEMBL4888133 | 0.80 | KDM4E (0.61) | KDM4EALDH1A1KMT2ANFKB1ATF1 | |
| SCHEMBL29038495 | 0.78 | TSHR (0.47) | KDM4EMAPTGAAALDH1A1NFKB1 | |
| SCHEMBL30468126 | 0.78 | TSHR (0.47) | KDM4EMAPTGAAALDH1A1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318389-B1 | PYRIDAZINE DERIVATIVES AS SMO INHIBITORS | NOVARTIS AG (CH) | 2013-06-19 | — | — | EP | disclosed |