Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | FPR1 | P21462 | 5/20 | 0.41 |
| ▸ | FPR2 | P25090 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4952000 | 0.91 | F10 (0.42) | SMN1; SMN2EPHX2L3MBTL1F10ALOX5 | |
| SCHEMBL12056138 | 0.88 | EPHX2 (0.45) | SMN1; SMN2EPHX2L3MBTL1ALOX5IDO1 | |
| SCHEMBL4268437 | 0.88 | EPHX2 (0.40) | SMN1; SMN2EPHX2L3MBTL1F10ALOX5 | |
| SCHEMBL4268432 | 0.88 | EPHX2 (0.40) | SMN1; SMN2EPHX2L3MBTL1F10ALOX5 | |
| SCHEMBL1504205 | 0.87 | — | — | |
| SCHEMBL1503901 | 0.86 | F10 (0.43) | SMN1; SMN2EPHX2L3MBTL1F10IDO1 | |
| SCHEMBL1503858 | 0.83 | F10 (0.42) | SMN1; SMN2L3MBTL1F10MAPK11MAPK14 | |
| SCHEMBL6362439 | 0.83 | EPHX2 (0.40) | SMN1; SMN2EPHX2L3MBTL1F10ALOX5 | |
| SCHEMBL4271910 | 0.80 | EPHX2 (0.39) | SMN1; SMN2EPHX2L3MBTL1F10ALOX5 | |
| SCHEMBL4271905 | 0.80 | EPHX2 (0.39) | SMN1; SMN2EPHX2L3MBTL1F10ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1405852-B9 | DIAMINE DERIVATIVES | DAIICHI SANKYO CO LTD (JP) | 2013-03-27 | — | — | EP | disclosed |
| EP-1405852-B1 | DIAMINE DERIVATIVES | DAIICHI SANKYO CO LTD (JP) | 2012-08-01 | — | — | EP | disclosed |
| US-20110312990-A1 | Diamine Derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2011-12-22 | — | — | US | disclosed |
| EP-2343290-A1 | Diamine derivatives as factor X inhibitors | Daiichi Sankyo Company, Limited (JP) | 2011-07-13 | — | — | EP | disclosed |
| US-20110077266-A1 | Diamine Derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2011-03-31 | — | — | US | disclosed |
| US-20100093785-A1 | DIAMINE DERIVATIVES | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2010-04-15 | — | — | US | disclosed |
| US-20090270446-A1 | DIAMINE DERIVATIVES | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2009-10-29 | — | — | US | disclosed |
| US-7365205-B2 | Cyclic diamine derivatives useful as agents for preventing and/or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism; inhibit activated blood coagulation factor X | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2008-04-29 | — | — | US | disclosed |
| US-7342014-B2 | Diamine derivatives | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2008-03-11 | — | — | US | disclosed |
| US-20080015215-A1 | DIAMINE DERIVATIVES | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2008-01-17 | — | — | US | disclosed |
| US-20050245565-A1 | Diamine derivatives | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2005-11-03 | — | — | US | disclosed |
| US-20050020645-A1 | Diamine derivatives | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2005-01-27 | — | — | US | disclosed |
| EP-1415992-A1 | DIAMINE DERIVATIVES | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2004-05-06 | — | — | EP | disclosed |
| EP-1405852-A1 | DIAMINE DERIVATIVES | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2004-04-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270446-A1 | DIAMINE DERIVATIVES | F2, TFPI, F3 | SMN1; SMN2 4166/4885EPHX2 482/4885L3MBTL1 4055/4885 |
| US-20050020645-A1 | Diamine derivatives | C9, C1S, C1R | SMN1; SMN2 473/4885EPHX2 3356/4885L3MBTL1 385/4885 |
| US-20080015215-A1 | DIAMINE DERIVATIVES | C9, C1S, C1R | SMN1; SMN2 473/4885EPHX2 3356/4885L3MBTL1 385/4885 |
| US-20050245565-A1 | Diamine derivatives | C9, C1S, C1R | SMN1; SMN2 473/4885EPHX2 3356/4885L3MBTL1 385/4885 |
| US-20100093785-A1 | DIAMINE DERIVATIVES | C9, C1S, C1R | SMN1; SMN2 666/4885EPHX2 2815/4885L3MBTL1 309/4885 |
| US-20110077266-A1 | Diamine Derivatives | F2, TFPI, F3 | SMN1; SMN2 4166/4885EPHX2 482/4885L3MBTL1 4055/4885 |
| US-20110312990-A1 | Diamine Derivatives | C9, C1S, C1R | SMN1; SMN2 656/4885EPHX2 3155/4885L3MBTL1 297/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.