Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 3/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | SLC5A1 | P13866 | 3/20 | 0.37 |
| ▸ | SLC5A2 | P31639 | 3/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15791371 | 0.89 | EPHX2 (0.46) | GRM5EPHX2ACACBHRH3APP | |
| SCHEMBL18784271 | 0.84 | EPHX2 (0.41) | GRM5EPHX2ACACB | |
| SCHEMBL2226844 | 0.83 | AKT1 (0.40) | ACACBHRH3SLC5A1SLC5A2LRRK2 | |
| SCHEMBL744274 | 0.83 | AKT1 (0.40) | ACACBHRH3SLC5A1SLC5A2LRRK2 | |
| SCHEMBL2230216 | 0.83 | AKT1 (0.40) | ACACBHRH3SLC5A1SLC5A2LRRK2 | |
| SCHEMBL21443397 | 0.81 | LRRK2 (0.43) | GRM5ACACBHRH3LRRK2 | |
| SCHEMBL4823837 | 0.81 | ALK (0.47) | EPHX2ACACBHRH3SLC5A1SLC5A2 | |
| SCHEMBL21051334 | 0.81 | ACACB (0.42) | ACACBHRH3SLC5A1SLC5A2 | |
| SCHEMBL21051305 | 0.81 | ACACB (0.42) | ACACBHRH3SLC5A1SLC5A2 | |
| SCHEMBL7760091 | 0.81 | LRRK2 (0.43) | GRM5ACACBHRH3LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013088256-A1 | SUBSTITUTED PYRAZOLO[1,5-A] PYRIDINE AS TROPOMYOSIN RECEPTOR KINASE (TRK) INHIBITORS | DR. REDDY'S LABORATORIES LTD. (IN) | 2013-06-20 | — | — | WO | disclosed |