Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | MC4R | P32245 | 11/20 | 0.43 |
| ▸ | MC3R | P41968 | 6/20 | 0.43 |
| ▸ | MC1R | Q01726 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 3/20 | 0.41 |
| ▸ | MC5R | P33032 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | CCNC | P24863 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12536899 | 1.00 | DPP4 (0.46) | DPP4MC4RMC3RMC1RRXFP1 | |
| SCHEMBL1946769 | 1.00 | DPP4 (0.46) | DPP4MC4RMC3RMC1RRXFP1 | |
| SCHEMBL15016124 | 0.88 | DPP4 (0.51) | DPP4MC4RMC3RMC1RRXFP1 | |
| SCHEMBL13493172 | 0.88 | DPP4 (0.51) | DPP4MC4RMC3RMC1RRXFP1 | |
| SCHEMBL12536955 | 0.88 | DPP4 (0.51) | DPP4MC4RMC3RMC1RRXFP1 | |
| SCHEMBL1919957 | 0.82 | MC4R (0.49) | MC4RMC3RMC1RMC5RKCNH2 | |
| SCHEMBL15039510 | 0.81 | MC4R (0.46) | MC4RMC3RMC1RMC5RKCNH2 | |
| SCHEMBL2307981 | 0.81 | KMT2A (0.49) | MC4RMC3RMC1RMC5RKCNH2 | |
| SCHEMBL18481477 | 0.79 | MC4R (0.52) | MC4RMC3RMC1RMC5RKCNH2 | |
| SCHEMBL15039509 | 0.78 | PANK3 (0.45) | MC4RMC3RMC1RMC5RKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2326638-B9 | DIAZEPINE AND DIAZOCANE COMPOUNDS AS MC4 AGONISTS | PFIZER LTD (GB) | 2013-11-13 | — | — | EP | disclosed |
| EP-2326638-B1 | DIAZEPINE AND DIAZOCANE COMPOUNDS AS MC4 AGONISTS | PFIZER LTD (GB) | 2013-06-19 | — | — | EP | disclosed |