Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 18/20 | 0.70 |
| ▸ | PIK3CA | P42336 | 14/20 | 0.70 |
| ▸ | PIK3CB | P42338 | 13/20 | 0.70 |
| ▸ | PIK3CG | P48736 | 12/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.70 |
| ▸ | MTOR | P42345 | 2/20 | 0.49 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.46 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14880326 | 0.91 | PIK3CD (0.72) | PIK3CDPIK3CAPIK3CBPIK3CGKCNH2 | |
| SCHEMBL14880809 | 0.86 | PIK3CD (0.66) | PIK3CDPIK3CAPIK3CBPIK3CGKCNH2 | |
| SCHEMBL14883816 | 0.83 | PIK3CD (0.55) | PIK3CDPIK3CAPIK3CBPIK3CGKCNH2 | |
| SCHEMBL14883855 | 0.83 | PIK3CD (1.00) | PIK3CDPIK3CAPIK3CBPIK3CGKCNH2 | |
| SCHEMBL14883865 | 0.82 | PIK3CD (0.82) | PIK3CDPIK3CAPIK3CBPIK3CGKCNH2 | |
| SCHEMBL182718 | 0.82 | PIK3CD (0.61) | PIK3CDPIK3CAPIK3CBPIK3CGKCNH2 | |
| SCHEMBL182805 | 0.82 | PIK3CD (0.58) | PIK3CDPIK3CAPIK3CBPIK3CGKCNH2 | |
| SCHEMBL14883896 | 0.81 | PIK3CD (0.84) | PIK3CDPIK3CAPIK3CBPIK3CGKCNH2 | |
| SCHEMBL14880713 | 0.81 | PIK3CD (0.82) | PIK3CDPIK3CAPIK3CBPIK3CGKCNH2 | |
| SCHEMBL14883895 | 0.81 | PIK3CD (0.74) | PIK3CDPIK3CAPIK3CBPIK3CGKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013088404-A1 | Use of inhibitors of the activity or function of PI3K | NOVARTIS AG (CH) | 2013-06-20 | — | — | WO | disclosed |