Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 14/20 | 0.42 |
| ▸ | CCND1 | P24385 | 13/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 10/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 9/20 | 0.42 |
| ▸ | CDK2 | P24941 | 9/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 8/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 8/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 8/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | WEE1 | P30291 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 2/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.37 |
| ▸ | CCND2 | P30279 | 2/20 | 0.37 |
| ▸ | CCND3 | P30281 | 2/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.37 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15034789 | 0.94 | CDK4 (0.40) | CDK4CCND1FGFR1CCNA2CDK2 | |
| SCHEMBL15041762 | 0.88 | CDK4 (0.42) | CDK4CCND1FGFR1CCNA2CDK2 | |
| SCHEMBL15034972 | 0.81 | CDK4 (0.40) | CDK4CCND1FGFR1CCNA2CDK2 | |
| SCHEMBL15041164 | 0.79 | CDK4 (0.44) | CDK4CCND1FGFR1CCNA2CDK2 | |
| SCHEMBL15237018 | 0.77 | WEE1 (0.47) | CDK4CCND1FGFR1CCNA2CDK2 | |
| SCHEMBL15041417 | 0.77 | WEE1 (0.45) | CDK4CCND1FGFR1CCNA2CDK2 | |
| SCHEMBL15041224 | 0.77 | CDK4 (0.50) | CDK4CCND1FGFR1CCNA2CDK2 | |
| SCHEMBL15041758 | 0.76 | CDK4 (0.42) | CDK4CCND1FGFR1CCNA2CDK2 | |
| SCHEMBL15041391 | 0.75 | CDK4 (0.41) | CDK4CCND1FGFR1CCNA2CDK2 | |
| SCHEMBL15035786 | 0.72 | FGFR1 (0.44) | CDK4CCND1FGFR1CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130231348-A1 | 8-(HETEROARYLMETHYL)PYRIDO[2,3-d]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS | AFRAXIS, INC. (US) | 2013-09-05 | — | — | US | disclosed |
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | AFRAXIS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130231348-A1 | 8-(HETEROARYLMETHYL)PYRIDO[2,3-d]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS | PAK2, PAK3, PAK5 | CDK4 408/4885CCND1 3984/4885FGFR1 2874/4885 |
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | PAK5, PAK2, PAK6 | CDK4 404/4885CCND1 2153/4885FGFR1 1919/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.