Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKN1 | Q16512 | 3/20 | 0.47 |
| ▸ | PAK3 | O75914 | 3/20 | 0.47 |
| ▸ | PAK1 | Q13153 | 3/20 | 0.47 |
| ▸ | PAK2 | Q13177 | 3/20 | 0.47 |
| ▸ | PAK4 | O96013 | 2/20 | 0.47 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.47 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.47 |
| ▸ | TNK2 | Q07912 | 7/20 | 0.42 |
| ▸ | CDK4 | P11802 | 9/20 | 0.41 |
| ▸ | CCND1 | P24385 | 9/20 | 0.41 |
| ▸ | CCND2 | P30279 | 3/20 | 0.41 |
| ▸ | CCND3 | P30281 | 3/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.40 |
| ▸ | CDK2 | P24941 | 7/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 6/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 6/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 6/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13553660 | 0.92 | PAK4 (0.47) | PKN1PAK3PAK1PAK2PAK4 | |
| SCHEMBL15785295 | 0.92 | PAK4 (0.48) | PKN1PAK3PAK1PAK2PAK4 | |
| SCHEMBL15041866 | 0.79 | CDK4 (0.42) | PKN1PAK3PAK1PAK2PAK4 | |
| SCHEMBL15041667 | 0.78 | PAK3 (0.49) | PKN1PAK3PAK1PAK2PAK4 | |
| SCHEMBL13553638 | 0.78 | CDK4 (0.49) | PKN1PAK3PAK1PAK2PAK4 | |
| SCHEMBL13553605 | 0.77 | TNK2 (0.51) | TNK2CDK4CCND1CCND2CCND3 | |
| SCHEMBL15785216 | 0.76 | TNK2 (0.51) | TNK2CDK4CCND1CCND2CCND3 | |
| SCHEMBL15041850 | 0.76 | PAK3 (0.56) | PKN1PAK3PAK1PAK2PAK4 | |
| SCHEMBL15041476 | 0.76 | TNK2 (0.51) | TNK2CDK4CCND1CCND2CCND3 | |
| SCHEMBL15034870 | 0.75 | PAK4 (0.53) | PKN1PAK3PAK1PAK2PAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | AFRAXIS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | PAK5, PAK2, PAK6 | PKN1 326/4885PAK3 6/4885PAK1 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.