Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 9/20 | 0.44 |
| ▸ | CCND1 | P24385 | 9/20 | 0.44 |
| ▸ | WEE1 | P30291 | 2/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.44 |
| ▸ | CDK9 | P50750 | 2/20 | 0.44 |
| ▸ | CCND2 | P30279 | 5/20 | 0.43 |
| ▸ | CCND3 | P30281 | 5/20 | 0.43 |
| ▸ | PAK4 | O96013 | 2/20 | 0.42 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.42 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 3/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.42 |
| ▸ | CDK2 | P24941 | 3/20 | 0.42 |
| ▸ | CSF1R | P07333 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15035680 | 0.94 | WEE1 (0.44) | CDK4CCND1WEE1CCNT1CDK9 | |
| SCHEMBL15041423 | 0.82 | CDK4 (0.48) | CDK4CCND1WEE1CCNT1CDK9 | |
| SCHEMBL15041180 | 0.75 | WEE1 (0.47) | CDK4CCND1WEE1CCNT1CDK9 | |
| SCHEMBL15035890 | 0.75 | CDK4 (0.48) | CDK4CCND1WEE1CCNT1CDK9 | |
| SCHEMBL15280101 | 0.75 | CDK4 (0.48) | CDK4CCND1CCND2CCND3JAK3 | |
| SCHEMBL15041417 | 0.74 | WEE1 (0.45) | CDK4CCND1WEE1CCNT1CDK9 | |
| SCHEMBL15237018 | 0.74 | WEE1 (0.47) | CDK4CCND1WEE1CCNT1CDK9 | |
| SCHEMBL15041254 | 0.74 | WEE1 (0.48) | CDK4CCND1WEE1CCNT1CDK9 | |
| SCHEMBL15035915 | 0.73 | CDK4 (0.35) | CDK4CCND1CCNT1CDK9CCND2 | |
| SCHEMBL15041434 | 0.73 | WEE1 (0.45) | CDK4CCND1WEE1CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130252967-A1 | 8-(SULFONYLBENZYL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS | AFRAXIS, INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | AFRAXIS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130252967-A1 | 8-(SULFONYLBENZYL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS | PAK2, PAK3, PAK6 | CDK4 441/4885CCND1 4422/4885WEE1 983/4885 |
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | PAK5, PAK2, PAK6 | CDK4 404/4885CCND1 2153/4885WEE1 545/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.