Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 13/20 | 0.53 |
| ▸ | STK4 | Q13043 | 3/20 | 0.48 |
| ▸ | STK3 | Q13188 | 3/20 | 0.48 |
| ▸ | SIK2 | Q9H0K1 | 3/20 | 0.48 |
| ▸ | STK26 | Q9P289 | 3/20 | 0.48 |
| ▸ | STK24 | Q9Y6E0 | 3/20 | 0.48 |
| ▸ | PKN1 | Q16512 | 4/20 | 0.45 |
| ▸ | PAK4 | O96013 | 3/20 | 0.45 |
| ▸ | PAK2 | Q13177 | 4/20 | 0.45 |
| ▸ | PAK3 | O75914 | 3/20 | 0.45 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.45 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.45 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.43 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14682038 | 0.91 | PAK1 (0.53) | PAK1STK4STK3SIK2STK26 | |
| SCHEMBL13553760 | 0.83 | PAK1 (0.44) | PAK1STK4STK3SIK2STK26 | |
| SCHEMBL15785356 | 0.78 | PAK1 (0.49) | PAK1STK4STK3SIK2STK26 | |
| SCHEMBL15036067 | 0.76 | TNK2 (0.41) | PAK1PKN1PAK2PAK3TNK2 | |
| SCHEMBL15785218 | 0.75 | TNK2 (0.44) | PAK1PKN1PAK4PAK2TNK2 | |
| SCHEMBL15787915 | 0.75 | TNK2 (0.43) | PAK1PKN1PAK4PAK2TNK2 | |
| SCHEMBL15785291 | 0.73 | PAK1 (0.41) | PAK1STK4STK3SIK2STK26 | |
| SCHEMBL15787934 | 0.73 | PKN1 (0.47) | PAK1STK4STK3SIK2STK26 | |
| SCHEMBL14824798 | 0.73 | PKN1 (0.65) | PAK1STK4STK3SIK2STK26 | |
| SCHEMBL12807687 | 0.72 | PKN1 (0.64) | PAK1STK4STK3SIK2STK26 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | AFRAXIS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | PAK5, PAK2, PAK6 | PAK1 4/4885STK4 272/4885STK3 333/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.