Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 7/20 | 0.37 |
| ▸ | SRC | P12931 | 3/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 7/20 | 0.37 |
| ▸ | NOD2 | Q9HC29 | 7/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 6/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.35 |
| ▸ | WEE1 | P30291 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14682045 | 0.92 | CHEK1 (0.41) | TNK2SRCRIPK2NOD2ACVR1 | |
| SCHEMBL13553770 | 0.88 | RIPK2 (0.37) | TNK2SRCRIPK2NOD2ACVR1 | |
| SCHEMBL14682089 | 0.79 | RIPK2 (0.37) | TNK2SRCRIPK2NOD2ACVR1 | |
| SCHEMBL15036069 | 0.78 | RIPK2 (0.45) | TNK2SRCRIPK2NOD2ACVR1 | |
| SCHEMBL15041536 | 0.75 | RIPK2 (0.42) | TNK2SRCRIPK2NOD2ACVR1 | |
| SCHEMBL14682001 | 0.74 | RIPK2 (0.47) | TNK2SRCRIPK2NOD2ACVR1 | |
| SCHEMBL15787914 | 0.73 | RIPK2 (0.43) | TNK2SRCRIPK2NOD2ACVR1 | |
| SCHEMBL15785223 | 0.72 | TNK2 (0.39) | TNK2SRCRIPK2NOD2ACVR1 | |
| SCHEMBL15785299 | 0.72 | RIPK2 (0.39) | TNK2SRCRIPK2NOD2ACVR1 | |
| SCHEMBL15036122 | 0.71 | RIPK2 (0.47) | TNK2SRCRIPK2NOD2ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | AFRAXIS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | PAK5, PAK2, PAK6 | TNK2 7/4885SRC 26/4885RIPK2 971/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.