Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 10/20 | 0.42 |
| ▸ | WEE1 | P30291 | 2/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 4/20 | 0.38 |
| ▸ | NOD2 | Q9HC29 | 4/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.37 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15036122 | 0.80 | RIPK2 (0.47) | TNK2RIPK2NOD2ACVR1FGFR1 | |
| SCHEMBL15041869 | 0.80 | CDK2 (0.42) | TNK2RIPK2NOD2ACVR1PAK4 | |
| SCHEMBL13553837 | 0.76 | TNK2 (0.38) | TNK2WEE1PAK4PKN1 | |
| SCHEMBL15041707 | 0.76 | RIPK2 (0.43) | TNK2WEE1RIPK2NOD2ACVR1 | |
| SCHEMBL14682124 | 0.76 | CCNT1 (0.40) | TNK2RIPK2NOD2ACVR1PAK4 | |
| SCHEMBL15041652 | 0.76 | TNK2 (0.43) | TNK2WEE1RIPK2NOD2ACVR1 | |
| SCHEMBL15036041 | 0.74 | PKN1 (0.46) | TNK2WEE1RIPK2NOD2ACVR1 | |
| SCHEMBL15281053 | 0.74 | RIPK2 (0.46) | TNK2RIPK2NOD2ACVR1FGFR1 | |
| SCHEMBL15036051 | 0.74 | CDK7 (0.48) | TNK2WEE1RIPK2NOD2ACVR1 | |
| SCHEMBL15041894 | 0.73 | RIPK2 (0.41) | RIPK2NOD2ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8912203-B2 | 6-(sulfonylaryl)pyrido[2,3-D]pyrimidin-7(8H)-ones for the treatment of CNS disorders | AFRAXIS HOLDINGS, INC. (US) | 2014-12-16 | — | — | US | disclosed |
| US-20130252966-A1 | 6-(SULFONYLARYL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS | AFRAXIS, INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | AFRAXIS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130252966-A1 | 6-(SULFONYLARYL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF CNS DISORDERS | PAK2, PAK6, PAK3 | TNK2 14/4885WEE1 1354/4885RIPK2 870/4885 |
| US-20130158043-A1 | PAK INHIBITORS FOR THE TREATMENT OF CANCER | PAK5, PAK2, PAK6 | TNK2 7/4885WEE1 545/4885RIPK2 971/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.