SCHEMBL15044796

SCHEMBL15044796

CN(NC(=O)CC(=O)NI)C(=S)c1ccccc1

nearest known ligand 0.85

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 2/20 0.85
HSP90AB1 P08238 1/20 0.85
ALDH1A1 P00352 6/20 0.44
MAPT P10636 3/20 0.44
LMNA P02545 1/20 0.38
HPGD P15428 3/20 0.37
RAB9A P51151 2/20 0.37
NPC1 O15118 1/20 0.37
SMN1; SMN2 Q16637 3/20 0.36
GAA P10253 2/20 0.36
KMT2A Q03164 3/20 0.36
MEN1 O00255 2/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
KDM4E B2RXH2 1/20 0.35
CYP3A4 P08684 1/20 0.35
ALOX15 P16050 1/20 0.35
CES1 P23141 1/20 0.35
MAPK1 P28482 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
EGFR P00533 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Elesclomol SCHEMBL313745 0.92 HSP90AA1 (1.00) HSP90AA1HSP90AB1ALDH1A1MAPTLMNA
Elesclomol SCHEMBL2819576 0.91 HSP90AA1 (0.97) HSP90AA1HSP90AB1ALDH1A1MAPTLMNA
SCHEMBL12354384 0.86 HSP90AA1 (0.88) HSP90AA1HSP90AB1ALDH1A1MAPTHPGD
SCHEMBL13943131 0.84 HSP90AA1 (0.84) HSP90AA1HSP90AB1ALDH1A1MAPTLMNA
SCHEMBL12808820 0.84 HSP90AA1 (0.84) HSP90AA1HSP90AB1ALDH1A1MAPTLMNA
SCHEMBL14295109 0.83 HSP90AA1 (0.82) HSP90AA1HSP90AB1ALDH1A1MAPTLMNA
SCHEMBL14301338 0.83 HSP90AA1 (0.76) HSP90AA1HSP90AB1ALDH1A1MAPTLMNA
SCHEMBL14301339 0.82 HSP90AA1 (0.80) HSP90AA1HSP90AB1ALDH1A1MAPTHPGD
SCHEMBL13042596 0.80 HSP90AA1 (0.77) HSP90AA1HSP90AB1ALDH1A1MAPTRAB9A
SCHEMBL13042587 0.80 HSP90AA1 (0.77) HSP90AA1HSP90AB1ALDH1A1MAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013090387-A1 METHOD OF TREATING NON-SMALL CELL LUNG CANCER WITH BIS-(THIOHYDRAZIDE)AMIDE COMPOUNDS SYNTA PHARMACEUTICALS CORP. (US) 2013-06-20 WO disclosed