Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 13/20 | 0.60 |
| ▸ | MAPT | P10636 | 11/20 | 0.60 |
| ▸ | APP | P05067 | 6/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | CASP6 | P55212 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.58 |
| ▸ | CASP1 | P29466 | 2/20 | 0.56 |
| ▸ | APAF1 | O14727 | 1/20 | 0.53 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.53 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.53 |
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16379200 | 0.90 | ADORA1 (0.49) | ADORA1MAPTAPPKDM4EALDH1A1 | |
| SCHEMBL16379119 | 0.90 | ADORA1 (0.49) | ADORA1MAPTAPPKDM4EALDH1A1 | |
| SCHEMBL16379103 | 0.88 | ADORA1 (0.78) | ADORA1MAPTAPPKDM4EALDH1A1 | |
| SCHEMBL15047100 | 0.88 | ADORA1 (0.78) | ADORA1MAPTAPPKDM4EALDH1A1 | |
| SCHEMBL15047083 | 0.85 | ADORA1 (0.74) | ADORA1MAPTAPPKDM4EALDH1A1 | |
| SCHEMBL15047111 | 0.84 | MAPT (0.57) | ADORA1MAPTAPPKDM4EALDH1A1 | |
| SCHEMBL16379190 | 0.84 | MAPT (0.57) | ADORA1MAPTAPPKDM4EALDH1A1 | |
| SCHEMBL15047050 | 0.84 | MAPT (0.59) | ADORA1MAPTAPPKDM4EALDH1A1 | |
| SCHEMBL15047093 | 0.82 | MAPT (0.59) | ADORA1MAPTAPPKDM4EALDH1A1 | |
| SCHEMBL16379147 | 0.81 | ADORA1 (0.52) | ADORA1MAPTAPPKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150004100-A1 | HETEROCYCLIC COMPOUNDS AS IMAGING PROBES OF TAU PATHOLOGY | GE HEALTHCARE LIMITED (GB) | 2015-01-01 | — | — | US | disclosed |
| US-20150004100-A1 | HETEROCYCLIC COMPOUNDS AS IMAGING PROBES OF TAU PATHOLOGY | GE HEALTHCARE LIMITED (GB) | 2015-01-01 | — | — | US | disclosed |
| WO-2013090497-A1 | HETEROCYCLIC COMPOUNDS AS IMAGING PROBES OF TAU PATHOLOGY | GE HEALTHCARE LIMITED (GB) | 2013-06-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150004100-A1 | HETEROCYCLIC COMPOUNDS AS IMAGING PROBES OF TAU PATHOLOGY | MAPT, NAT1, APP | ADORA1 438/4885MAPT 1/4885APP 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.