Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 12/20 | 0.80 |
| ▸ | MAPT | P10636 | 12/20 | 0.80 |
| ▸ | APP | P05067 | 5/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.80 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.80 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.80 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.80 |
| ▸ | CASP6 | P55212 | 1/20 | 0.80 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.78 |
| ▸ | CASP1 | P29466 | 2/20 | 0.75 |
| ▸ | MEN1 | O00255 | 1/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.75 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.75 |
| ▸ | APAF1 | O14727 | 1/20 | 0.71 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.71 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15047100 | 0.93 | ADORA1 (0.78) | ADORA1MAPTAPPKDM4EALDH1A1 | |
| SCHEMBL16379103 | 0.93 | ADORA1 (0.78) | ADORA1MAPTAPPKDM4EALDH1A1 | |
| SCHEMBL7877231 | 0.89 | ADORA1 (1.00) | ADORA1MAPTAPPKDM4EALDH1A1 | |
| SCHEMBL14660061 | 0.88 | MAPT (0.88) | ADORA1MAPTAPPKDM4EALDH1A1 | |
| SCHEMBL16379167 | 0.88 | MAPT (1.00) | ADORA1MAPTAPPKDM4EALDH1A1 | |
| SCHEMBL14659972 | 0.87 | ADORA1 (1.00) | ADORA1MAPTAPPKDM4EALDH1A1 | |
| SCHEMBL1491866 | 0.86 | ADORA1 (0.81) | ADORA1MAPTAPPKDM4EALDH1A1 | |
| SCHEMBL1491896 | 0.86 | MAPT (0.84) | ADORA1MAPTAPPKDM4EALDH1A1 | |
| SCHEMBL16379138 | 0.86 | MAPT (1.00) | ADORA1MAPTAPPKDM4EALDH1A1 | |
| SCHEMBL1491879 | 0.86 | ADORA1 (1.00) | ADORA1MAPTAPPKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013090497-A1 | HETEROCYCLIC COMPOUNDS AS IMAGING PROBES OF TAU PATHOLOGY | GE HEALTHCARE LIMITED (GB) | 2013-06-20 | — | — | WO | disclosed |