Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.33 |
| ▸ | ESR1 | P03372 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PHGDH | O43175 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14855774 | 1.00 | HRH3 (0.38) | HRH3SIGMAR1MEN1ALDH1A1KMT2A | |
| SCHEMBL14856258 | 1.00 | HRH3 (0.38) | HRH3SIGMAR1MEN1ALDH1A1KMT2A | |
| SCHEMBL5998295 | 1.00 | HRH3 (0.38) | HRH3SIGMAR1MEN1ALDH1A1KMT2A | |
| SCHEMBL14915000 | 1.00 | HRH3 (0.38) | HRH3SIGMAR1MEN1ALDH1A1KMT2A | |
| SCHEMBL806361 | 1.00 | HRH3 (0.38) | HRH3SIGMAR1MEN1ALDH1A1KMT2A | |
| SCHEMBL5995166 | 1.00 | HRH3 (0.38) | HRH3SIGMAR1MEN1ALDH1A1KMT2A | |
| SCHEMBL5971686 | 1.00 | HRH3 (0.38) | HRH3SIGMAR1MEN1ALDH1A1KMT2A | |
| SCHEMBL26446019 | 0.88 | KDM4E (0.41) | HRH3MEN1ALDH1A1KMT2AKDM4E | |
| SCHEMBL26433911 | 0.88 | KDM4E (0.41) | HRH3MEN1ALDH1A1KMT2AKDM4E | |
| SCHEMBL26433881 | 0.88 | KDM4E (0.41) | HRH3MEN1ALDH1A1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107531722-B | Heterocyclic estrogen receptor modulators and uses thereof | 豪夫迈·罗氏有限公司 | 2020-07-17 | — | — | CN | disclosed |
| WO-2013090829-A1 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | ARAGON PHARMACEUTICALS, INC. (US) | 2013-06-20 | — | — | WO | disclosed |