Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 16/20 | 0.84 |
| ▸ | NPM1 | P06748 | 11/20 | 0.84 |
| ▸ | INSR | P06213 | 8/20 | 0.84 |
| ▸ | JAK2 | O60674 | 5/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | MET | P08581 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL520358 | 0.92 | ALK (0.78) | ALKNPM1INSRJAK2KCNH2 | |
| SCHEMBL520037 | 0.92 | ALK (0.78) | ALKNPM1INSRJAK2KCNH2 | |
| SCHEMBL520036 | 0.92 | ALK (0.78) | ALKNPM1INSRJAK2KCNH2 | |
| SCHEMBL522072 | 0.92 | ALK (1.00) | ALKNPM1INSRJAK2KCNH2 | |
| SCHEMBL521122 | 0.90 | ALK (0.80) | ALKNPM1INSRJAK2CYP3A4 | |
| SCHEMBL520256 | 0.89 | ALK (0.94) | ALKNPM1INSRJAK2KCNH2 | |
| SCHEMBL520530 | 0.88 | ALK (0.81) | ALKNPM1INSRJAK2KCNH2 | |
| SCHEMBL520159 | 0.88 | ALK (0.84) | ALKNPM1INSRJAK2KCNH2 | |
| SCHEMBL520184 | 0.88 | ALK (0.84) | ALKNPM1INSRJAK2KCNH2 | |
| SCHEMBL520519 | 0.88 | ALK (0.83) | ALKNPM1INSRJAK2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-B1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON INC (US) | 2015-03-04 | — | — | EP | claimed |
| US-8471005-B2 | Pyrrolotriazines as ALK and JAK2 inhibitors | CEPHALON, INC. (US) | 2013-06-25 | — | — | US | claimed |
| EP-2376491-B1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON INC (US) | 2015-03-04 | — | — | EP | disclosed |
| US-8471005-B2 | Pyrrolotriazines as ALK and JAK2 inhibitors | CEPHALON, INC. (US) | 2013-06-25 | — | — | US | disclosed |