Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 18/20 | 0.82 |
| ▸ | NPM1 | P06748 | 16/20 | 0.82 |
| ▸ | INSR | P06213 | 9/20 | 0.75 |
| ▸ | JAK2 | O60674 | 4/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.67 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL522571 | 0.98 | ALK (0.85) | ALKNPM1INSRJAK2KCNH2 | |
| SCHEMBL521123 | 0.98 | ALK (0.85) | ALKNPM1INSRJAK2KCNH2 | |
| SCHEMBL521574 | 0.94 | ALK (0.77) | ALKNPM1INSRJAK2KCNH2 | |
| SCHEMBL520489 | 0.91 | ALK (0.88) | ALKNPM1INSRJAK2KCNH2 | |
| SCHEMBL520490 | 0.91 | ALK (0.88) | ALKNPM1INSRJAK2KCNH2 | |
| SCHEMBL520523 | 0.90 | ALK (1.00) | ALKNPM1INSRJAK2KCNH2 | |
| SCHEMBL520524 | 0.90 | ALK (1.00) | ALKNPM1INSRJAK2KCNH2 | |
| SCHEMBL520562 | 0.90 | ALK (0.86) | ALKNPM1INSRJAK2KCNH2 | |
| SCHEMBL519555 | 0.89 | ALK (0.83) | ALKNPM1INSRJAK2KCNH2 | |
| SCHEMBL519554 | 0.89 | ALK (0.83) | ALKNPM1INSRJAK2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-B1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON INC (US) | 2015-03-04 | — | — | EP | disclosed |
| US-8471005-B2 | Pyrrolotriazines as ALK and JAK2 inhibitors | CEPHALON, INC. (US) | 2013-06-25 | — | — | US | disclosed |