Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL521673 | 0.74 | JAK2 (0.62) | JAK2PTK2 | |
| SCHEMBL522091 | 0.74 | JAK2 (0.53) | JAK2PTK2 | |
| SCHEMBL522389 | 0.69 | JAK2 (0.60) | JAK2PTK2 | |
| SCHEMBL521144 | 0.69 | JAK2 (0.70) | JAK2PTK2 | |
| SCHEMBL3478587 | 0.64 | JAK2 (0.44) | JAK2PTK2 | |
| SCHEMBL521385 | 0.60 | JAK2 (0.56) | JAK2PTK2 | |
| SCHEMBL521246 | 0.58 | JAK2 (0.52) | JAK2PTK2 | |
| SCHEMBL524289 | 0.57 | JAK2 (0.40) | JAK2 | |
| SCHEMBL520185 | 0.57 | JAK2 (0.76) | JAK2 | |
| SCHEMBL521803 | 0.57 | JAK2 (0.76) | JAK2PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-B1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON INC (US) | 2015-03-04 | — | — | EP | disclosed |
| US-8471005-B2 | Pyrrolotriazines as ALK and JAK2 inhibitors | CEPHALON, INC. (US) | 2013-06-25 | — | — | US | disclosed |