Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 9/20 | 0.67 |
| ▸ | INSR | P06213 | 8/20 | 0.67 |
| ▸ | JAK2 | O60674 | 12/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | NPM1 | P06748 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL521808 | 0.95 | ALK (0.74) | ALKINSRJAK2CYP3A4NPM1 | |
| SCHEMBL15048653 | 0.90 | ALK (0.65) | ALKINSRJAK2CYP3A4NPM1 | |
| SCHEMBL521512 | 0.84 | ALK (0.72) | ALKINSRJAK2CYP3A4NPM1 | |
| SCHEMBL519959 | 0.84 | ALK (0.69) | ALKINSRJAK2CYP3A4NPM1 | |
| SCHEMBL521757 | 0.84 | ALK (0.76) | ALKINSRJAK2CYP3A4 | |
| SCHEMBL520545 | 0.83 | JAK2 (0.79) | ALKINSRJAK2CYP3A4NPM1 | |
| SCHEMBL519479 | 0.81 | ALK (1.00) | ALKINSRJAK2CYP3A4NPM1 | |
| SCHEMBL520678 | 0.79 | JAK2 (1.00) | ALKINSRJAK2CYP3A4NPM1 | |
| SCHEMBL521463 | 0.79 | JAK2 (0.77) | ALKINSRJAK2CYP3A4NPM1 | |
| SCHEMBL16530836 | 0.79 | JAK2 (0.71) | ALKINSRJAK2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-B1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON INC (US) | 2015-03-04 | — | — | EP | disclosed |
| US-8471005-B2 | Pyrrolotriazines as ALK and JAK2 inhibitors | CEPHALON, INC. (US) | 2013-06-25 | — | — | US | disclosed |